The issue with Setsuki in Mac builds is claimed fixed in the wild west branch (not yet in the public steam branch). Since the claimed fix, I DID see the issue one time with Setsuki in the editor we use internally. So maybe not fixed...but I would have expected to see it something like 100 times over the weeks involved, so maybe it's 100x less likely. I have not seen Setsuki broken in a build since the claimed fix. (Again, remember the fix isn't in the public Steam branch at the time of this writing, but will be within a week.)
Valerie's issue is not even claimed fixed in any Mac version. It's been well-known to use for many weeks, but we don't have a fix yet.
When encountering either issue, each time you restart the game, it seems to give you a random chance that the issue is fixed.